ZONA
FERTILITY JOURNAL
✓ EVIDENCE BASED
✓ TRYING TO CONCEIVE

If You're Planning to Have Kids in the Next 12 Months, Read This First

The research I did at 39 completely changed the journey to my daughter.
Ashley Calvin
12 min read
01

It’s me, the mom group lurker

At 11:43pm the night before my 39th birthday, I was sitting on the edge of my bathtub, lurking in an online mom group.

The end of the post read: “Please drop your stories of getting pregnant naturally after 38 and everything went well.”

Photo accompanying Ashley Calvin's story

I ran to the comments so fast.

But once I was there, I switched to another app.

I guess I was scared to read the things I didn’t want to see.

Stories of failure, resorting to IVF, bad news at the ultrasound or the bloodwork.

I had been not-trying-not-preventing for several months now and was starting to worry.

I knew I should take it seriously, but I kept talking myself into one more chill month.

The chill month was a lie. I wasn’t being chill. I was lurking in a mom group.

Eventually I sucked it up and read the list.

Somebody got pregnant accidentally at 42.

Okay, okay. That's what I want to see.

Someone else had success after figuring out she’d been ovulating early.

Then someone who failed IVF twice and wiped out her savings.

Deep breath. Keep going.

Someone had two late term losses and is still trying.

Shit. That’s the one I didn’t want to see.

Someone else mentions that this list is full of survivor’s bias.

Well, obviously.

I almost commented back to her, feeling pissed that she was pointing out the thing I knew was true.

That my self reassurance wasn’t based on anything and couldn’t actually predict my future success.

It’s so annoying when a stranger on the internet is right.

Nothing I read ever made me feel better. No one’s story calmed my nerves.

Because I was never scared about women in general.

I was afraid I wouldn’t be able to have a baby.

I was worried about my body. My egg.

My future kid with one of the names currently living in my Notes app.

So instead of trying to talk myself into optimism again, which I already knew wouldn’t work, I decided to do the scariest thing possible.

I started researching every single medical statistic I could find.

Every study. Every randomized control trial.

I spent all my free time obsessing over this. I became extraordinarily annoying to talk to at social gatherings.

But like the type-A millennial woman I am, I got to the bottom of it.

And the answers I found were better than 1,000 success stories from any forum or facebook group.

02

The 35 year old cutoff is a 350-year-old lie

Let’s start with one that had me screaming from my Instagram stories for weeks, shall we?

You know the deadline.

Cliff at 35. Better find that man quick. Freeze your eggs or else.

Every woman knows the boogeyman comes out at 35.

We say that age like it’s a given, but guess where it comes from?

Baptism records from a village parish in France between 1670 and 1830.

That is not a joke.

I’m not making this shit up.

In 1986 Jane Menken published a paper called “Age and Infertility” in one of the largest scientific publications on the planet and using 300-year-old stats from women who lived before lightbulbs.

That paper has since been cited over 1100 times by other studies, meta analyses, and medical textbooks.

Human Reproduction journal citation showing French birth records data 1670–1830

That’s how one study becomes an urban legend so strong even my doctor was quoting it.

The cutoff I was most afraid of comes from an era before antibiotics.

Wtf.

Okay, I thought. Maybe all of this is bullshit then.

I dug further.

Sadly, the full story is not ‘aging affects nothing, go about your life and stop worrying.’

I wanted it to be that.

But I came here for the whole truth, not one fact that would make me feel better, so I kept digging.

And I found something even better.

03

Fertility is a lever, not a level

Turns out everyone’s fertility is going down.

1 in 6 couples can’t conceive.

Stay with me, it gets better.

That’s not one of the stats I was hoping to find.

But weirdly, it did make me feel a little better to know that fertility decline was happening across all ages, so it’s not like I missed some magic window.

Probably not the nicest thing to say, but it is what I was thinking.

So I typed this into Google: “Why is infertility going up?”

The answer was:
Chronic stress
Obesity
Autoimmunity
Chronic illness
Endocrine disruptors
Aging

Okay, I thought. How much of this is actually age?

After three full weekends of studies on PubMed, ChatGPT cross references, and endless Reddit comments, I stumbled onto this headline:

“Researchers reverse fertility decline in aging mice.”

Fastest I’ve ever clicked on anything in my life.

I didn’t care if it was clickbait.

But it wasn’t.

In a legitimate clinical trial, researchers actually took older mice and successfully gave them the fertility benefits of their youth.

These mice started ovulating more eggs, having more offspring, and the baby mice were healthy.

Egg quality improvements
egg quality ↑ time → nutrients added
No treatment
With nutrients
Source: Ben-Meir et al., Aging Cell, 2015.

Then other studies retested and had the same success.

Another study, and another, and another.

This was blowing my mind.

On some level, fertility could be controlled.

I forced myself into bed finally around 3AM, so hyped that it still took me an hour to drift off.

04

How controllable is fertility?

I skipped work the next day.

Overcaffeinated, with four different drinks sitting beside my keyboard, I read:

Improving mitochondrial function and reducing oxidative stress in the aging population lead to healthier oocytes and more, healthier offspring.

I read it again. I took another sip of coffee.

So basically:

If you can improve cellular health, you can improve pregnancy outcomes.

And what do you know?

All those factors that are the causes of the infertility crisis?

Chronic stress
Obesity
Autoimmunity
Chronic illness
Endocrine disruptors
Aging

Each of these either causes or is caused by poor cellular health.

It sounds like bad news, but I was ecstatic.

This is basically just like those biological age vs real age things.

This might be CONTROLLABLE.

Not like a random biological clock that I just have to stare at as my anxiety climbs.

I can do control.

Control and I are friends.

We go way back.

So I scroll down to the densest part of each of the 42 clinical studies I have open on my laptop and start comparing methods.

PubMed Central study open alongside many research tabs

Each of these studies improved cellular health by using specific nutrients that either:

Improve mitochondrial function
(i.e. provide your cells with more battery power)
Reduce cellular oxidation
(i.e. keep the cells looking and acting younger)
Improve intracellular communication
(i.e. give the cells a way to operate well together)

Everything else is downstream from these three.

If you improve these, egg health gets better.

Fertility rates improve.
Cell division works better.
Loss rates go down.
Babies are healthier.

Eggs take 90 days to develop before they ovulate, so if I did this right, in three months I could have an egg healthier than the ones I was producing a year ago.

Maybe even five years ago.

I started pouring through countless studies, acronyms, and dosing charts.

I was determined to figure out what worked, and how, and what I could use on myself.

05

The spreadsheet to end all spreadsheets

Since sex ed in the 7th grade I believed my eggs were aging with me.

That I was born with all of them, and by the time I was 30 they would be running out.

And that’s kind of true.

But here’s what Mrs. Linley (and my future OB/GYNs) didn’t tell me:

That egg isn’t just aging.

It’s building.

For 90 days before ovulating, that egg is heavily impacted by everything going on in my body.

this is the window where egg health can be changed

once each egg ovulates, its quality is unchangeable.

90 DAYS
before ovulation
OVULATION → PREGNANCY
1st trimester
2nd trimester
3rd trimester
about 40 weeks

That egg development window is when researchers were giving patients these nutrients.

Specific vitamins, specific minerals, specific time frames.

So I did what any good Capricorn would do.

I opened Excel and made a master list of every nutrient proven to work.

Then I took that list and compared it to the prenatal I had been taking.

It was a good one, not the $12 one from Costco.

I had bought it from a brand run by doctors.

I figured it would probably cover a lot of what had been proven to improve cellular health and I could buy whatever else I needed on Amazon.

Except it didn’t.

Actually, it wasn’t even close.

The doses were too small.

Many of the most important ones were missing altogether.

The forms were wrong.

They were using cheaper, less bioavailable forms at smaller doses or not at all.

Four supplements held in a hand

What the hell was the point of taking this?

I thought I was doing the most. I had given myself brownie points for being prepared in advance.

Back at my laptop, I started looking up other prenatals to see if I could find a better one.

I didn’t.

But I did find this study:

Commercial Available Prenatal Vitamins Do Not Meet American College of Obstetrics and Gynecologists Nutritional Guidelines

Turns out there isn’t a prenatal that follows the research.

There isn’t even one that meets the bare minimum guidelines from the medical group that says “This is what pregnant women need.”

I went into a bit of a rage.

How are they even allowed to sell these things?!

How would I have possibly known that?

What if I had gotten pregnant and something had happened because I wasn’t getting what I should have?

06

You should see my Amazon cart

I quit my research project for a few days and spent my free time lifting heavy things to 2000s hip hop at the gym instead.

By day 5 I decided to go to Amazon and fill a cart with everything on my spreadsheet.

Every single supplement studied and proven to help.

I could turn one of my cabinets into a pharmacy.

I’d have to basically meal prep supplements, but I was ready to do it right.

All in.

Or, I felt all in until I spent 2 hours assembling all the right bottles in my cart and looked at the total.

$784.68

Amazon shopping cart with 21 supplement items totaling $784.68

I made a weird, loud half-groan sound. My dog flinched.

I worked out the math.

I told myself that $780 a month for a few months was still a lot less than one round of IVF.

Much less than the cost of a single unexpected infant health issue.

But I still couldn’t pull the trigger.

I left my cart there, full of a thousand different bottles I had already sorted into those giant pill organizers grandmas use.

07

How healthy are my cells?

I decided to most rational thing was to try to convince myself this wasn’t necessary.

I had to play devil’s advocate for a minute.

I went searching for evidence that $780 a month of vitamins wouldn’t make a difference, just in case.

I eat healthy. I go to pilates. I drink green juice on a regular basis.

I might not need this.

I looked for evidence that could prove my other data wrong, and my searches all led me back to the same thing.

93%
of American adults test positive for metabolic dysfunction

And it’s not an obesity problem, even though a lot of us have been taught that metabolism = weight.

It turns out, metabolism = cellular health.

Most people who consider themselves healthy, people who eat well and exercise, people who are a healthy weight and describe themselves as feeling good, still have metabolic dysfunction when tested.

I'm one of those healthy eating regular(ish) exercisers. But just on statistics alone, the likelihood that my cells were in excellent shape was low.

I wanted to believe that I was in the 7% who were good, but am I?

What if I’m not?

What if I’m in the 93%?

Did it matter?

I decided the smart thing to do was cover my bases.

I was talking myself into the $780 per month Amazon cart when a positive pregnancy test popped up on my Instagram feed.

Some influencer had just found out she was expecting.

I almost scrolled past, not excited to see one more person getting what I wanted.

But then I read the text on the photo.

08

I struck gold while doomscrolling

“Your prenatal can’t do this."

No shit, I thought.

I kept reading.

“450mg of choline is critical for a healthy baby brain. Your prenatal contains 0mg.”

I was hooked. I hadn’t come across a real person talking about this anywhere.

The next line:

“600mg of CoQ10 is a game changer for egg quality. Your fertility vitamin contains 150mg of the wrong form.”

SOMEONE ELSE KNOWS.

Suddenly this influencer was my new best friend.

I was cheering her positive test on.

That could be MY positive test.

I read some more.

“I’ve been a nutritionist for over a decade, and I read every ingredient label that goes in by body. That’s how I found Zona. I took it while I started trying to conceive to give my kid the best start.”

Did I strike gold while doomscrolling?

I had never run to the comments section of a post so fast.

I scrolled through dozens of congratulations until I found a few women saying they also swore by Zona.

Three seconds later I had a new tab open to the Zona home page.

I ran through the science, looking for the ingredients before anything else.

Grabbing my laptop, I clicked over to my slightly insane looking nutrient spreadsheet so I could compare apples to apples.

600mg CoQ10 in Ubiquinol form, split into two 300mg doses - check.
1,000mg Omega 3 - check.
600mg NAC - check.
600mg choline - check.
1000mg methylfolate - check.
Vitamins A through K at research validated doses - check.

The list goes on.

ZONA Fertility Protocol product page

Zona had everything I had put in my Amazon cart plus a kick of magnesium and other minerals.

The doses were pre-packaged, separated out, and organized for bioavailability.

And it was $550 a month less than buying everything in my Amazon cart.

I let out a breath that I didn’t realize I was holding.

I could do this.

And it hit me.

I was going to have a baby.

I legitimately got a little teary, which is insane, I know.

But I’ve spent so much of my life carrying the weight of things for other people, and suddenly it felt like someone was carrying one for me.

I clicked checkout and slept better than I had in weeks.

Formulated with physicians and researchers in reproductive medicine and mitochondrial science.

ZONA Egg Protocol Zona protocol box, open ZONA Egg Protocol supplement facts label
4.9

ZONA Egg Protocol

Two daily packets. One with breakfast, one with dinner.

27 actives built to support a healthy pregnancy in the 90 days before conception.

90-day guarantee
Free shipping, always
Research based

Zona is designed to be taken before conception to give your egg and your baby the best possible start.

Two packets per day, pre-dosed.

Rip one open with breakfast and one with dinner. Sleep well knowing you've hit every input.

30
AM dose
7 capsules · with breakfast
× 30
CoQ10 (Ubiquinol)
300mg
DHA (triglyceride-form)
300mg
Vitamin D3
4,000 IU
Vitamin K2 (MK-7)
100mcg
Vitamin E (mixed tocopherols)
200 IU
Choline (Alpha-GPC + bitartrate)
600mg elemental
Vitamin C
500mg
Methylfolate (Quatrefolic®)
1,000mcg
Vitamin B12 (methyl + adenosylcobalamin)
500mcg
Vitamin B1 (thiamin)
5mg
Vitamin B2 (R5P)
5mg
Vitamin B3 (niacinamide)
20mg
Vitamin B5 (pantothenic acid)
10mg
Vitamin B6 (P5P)
25mg
Biotin
300mcg
Vitamin A (retinyl palmitate)
2,500 IU
Iron (Ferrochel®)
18mg
Iodine
150mcg
Selenium (selenomethionine)
200mcg
Chromium (picolinate)
200mcg
Copper (bisglycinate)
750mcg
Manganese (bisglycinate)
5mg
Molybdenum (glycinate)
100mcg
30
PM dose
4 capsules · with dinner
× 30
CoQ10 (Ubiquinol)
300mg
NAC
600mg
Alpha-Lipoic Acid
600mg
Acetyl-L-Carnitine
500mg
Zinc (bisglycinate)
25mg
PQQ
20mg
Magnesium (glycinate)
200mg
1 Open the box.
2 Take the AM packet with breakfast.
3 Take the PM packet with dinner.

Nothing for you to mix, weigh, schedule, or remember. Two packets a day.

Zona is designed from the last 15 years of breakthroughs in egg quality, mitochondrial health, and fetal development.

Every active is dosed to the clinical literature, not the bare-minimum RDA, and delivered in its most bioavailable form. Each batch is rigorously third-party tested for purity, potency, and contaminants, so what's on the label is exactly what's in the packet.

We built Zona for one reason: to give as many babies as possible the healthiest start we can.

Better odds of
getting pregnant
ZONA capsules arranged side by side Better odds of
staying pregnant

Zona is a twice daily supplement taken for 90 days before conception to support a healthy pregnancy before it begins.

Start the Egg Protocol
Physician formulated
Third-party tested
Research backed